Neurobiology of Disease Overexpression of the Astrocyte Glutamate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, and Forelimb Motor Dysfunction following Cervical Contusion Spinal Cord Injury
نویسندگان
چکیده
Ke Li,1* Charles Nicaise,1,2* Daniel Sannie,1 X Tamara J. Hala,1 Elham Javed,1 Jessica L. Parker,1 Rajarshi Putatunda,1 Kathleen A. Regan,1 Valérie Suain,3 Jean-Pierre Brion,3 Fred Rhoderick,4 Megan C. Wright,5 David J. Poulsen,4 and Angelo C. Lepore1 1Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University Medical College, Philadelphia, Pennsylvania 19107, 2Neurodegeneration and Regeneration Unit, L’Unité de Recherché en Physiologie Moléculaire–Namur Research Institute for Life Sciences, University of Namur, B-5000 Namur, Belgium, 3Laboratory of Histology, Neuroanatomy and Neuropathology, Université Libre de Bruxelles, B-1070 Brussels, Belgium, 4Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, and 5Department of Biology, Arcadia University, Glenside, Pennsylvania 19038
منابع مشابه
Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.
A major portion of spinal cord injury (SCI) cases affect midcervical levels, the location of the phrenic motor neuron (PhMN) pool that innervates the diaphragm. While initial trauma is uncontrollable, a valuable opportunity exists in the hours to days following SCI for preventing PhMN loss and consequent respiratory dysfunction that occurs during secondary degeneration. One of the primary cause...
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A primary cause of morbidity and mortality following cervical spinal cord injury (SCI) is respiratory compromise, regardless of the level of trauma. In particular, SCI at mid-cervical regions targets degeneration of both descending bulbospinal respiratory axons and cell bodies of phrenic motor neurons, resulting in deficits in the function of the diaphragm, the primary muscle of inspiration. Co...
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Respiratory compromise due to phrenic motor neuron loss is a debilitating consequence of a large proportion of human traumatic spinal cord injury (SCI) cases (1) and is the ultimate cause of death in patients with the motor neuron disorder, amyotrophic laterals sclerosis (ALS) (2). ALS is a devastating neurological disorder that is characterized by relatively rapid degeneration of upper and low...
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